Prism 10.4.0

Prism 10.4.0 was released on October 29, 2024.

Welcome to Prism 10.4.0!

New nonlinear dose-response models

This release introduces two new dose-response models for nonlinear regression. The Gaddum-Schild dose-response model is used for fitting to response data in the presence of a competitive inhibitor. As the concentration of inhibitor is increased, the resulting dose-response curve will shift to higher concentration values. Prism's original Gaddum-Schild models determine a best-fit value for the SchildSlope which quantifies how well this shift of the dose-response curve corresponds to the predicted shift due to competitive inhibition. Two new models (one for data when X is concentration and another for when X is log(concentration)) constrain the SchildSlope to its standard value of 1.0, simplifying the model fitting.

More intuitive controls for multiple variable heat maps

The axis controls for customizing heat maps generated from multiple variables data have been improved to be more intuitive and easier to use*. Because the axes of these graphs are categorical, controls designed for continuous values didn't quite make sense. So these controls have been re-designed to work for these categorical axes, making it easier to customize these graphs. These new controls can be found both in the Format Axes dialog as well as the Graph Inspector for multiple variables graphs.

A new integration with Dotmatics Luma

Make the most of your data and results from Prism through our new integration with Dotmatics Luma*, a Scientific Intelligence Platform designed to streamline research with AI-driven, adaptive workflows and seamless data integration.

By connecting Prism to Luma you can seamlessly automate sending your Prism files to a centralized location. There, your data and results will be extracted, parsed, and made available for easy downstream access, helping scientists and administrators unify and analyze large volumes of data for better decision-making.

* Available only for subscriptions with Prism Enterprise licenses

Complete Release Notes

New Features

Introduced two new Gaddum-Schild equations (with a fixed SchildSlope parameter) for nonlinear regression
Prism integration with Luma (Lab Connect)

Feature Improvements

Updated the results reported by existing Gaddum-Schild equations (with variable SchildSlope parameter) for nonlinear regression
Improved the "Regularly spaced ticks" options in the Format Axes dialog to be more intuitive for heat maps built from multiple variables tables
Enabled the "Number format" dropdown in the "Regularly spaced ticks" section of the "Format Axes" dialog for heat maps built from multiple variables tables
Improved discoverability of axis formatting options for heat maps by adding a link to the Format Axes dialog from the labels tab of the Heat Map GDO in the Format Graph dialog
Added the "Color for non-numeric values" checkbox to the "Fill and Border" sub-tab of the "Data" tab of the Graph Inspector for heat maps
Improved the file auto-recovery feature so that Prism can open files with corrupted links to analysis constants
Added the titles to the color and transparency controls in the Graph Inspector to remove ambiguity about "transparency" vs "opacity"
Improved reporting of equality of variance tests such that Prism will now report results with as few as two data points in each group
(Mac) Made it more clear how to re-define inappropriate data chosen to build a multiple variables graph by making the "Axis Variables" text in the hint that is shown in the "Format Graph" dialog as a link to the "Axis Variables" tab of the dialog
(Mac) Enabled options to format symbols, connecting lines/curves and bars/droplines/spikes in the Format Graph dialog for graphs generated by the Normalize analysis
(Mac) Enabled symbol formatting controls in the Format Graph dialog for XY graphs generated from green results sheets where the X column was a series of values
(Mac) Improved the behavior of selecting graphs in the graph gallery mode so that the checkbox on a graph preview thumbnail is checked when clicking either the checkbox itself or the checkbox title

Performance

Fixed the issue in which Prism unexpectedly recalculated the results of a "child" analysis an extra time upon switching to it if the "Recalculate All" operation was previously performed from the "parent" results sheet
(Windows) Fixed the issue in which Prism 10.3.0-10.3.1 was slower than previous versions while switching between graph and layout sheets that contained a large number of drawing objects
(Windows) Fixed the issue in which a long delay was observed while opening the "Parameters: Select and Transform" dialog on an analysis containing more than five transforms
(Windows) Fixed the issue in which Prism would crash while importing large quantities of data

Analysis-related Bug Fixes

Fixed the issue in which Prism would crash when performing the "K-means clustering analysis" from a survival data table with more than two groups
Fixed the issue in which values in the X column of the Curve/Line results tabs of Nonlinear and Linear regression analyses were unexpectedly altered if the same value was set as the start and end of the curve/line in the parameters dialog
Fixed the issue in which the "Use X values from the data table" radio button was disabled in the "Parameters: Simulate XY data" dialog if the source data table did not contain Y values
(Mac) Fixed the issue in which the disabled "Assume the baseline is linear with X" option was used for selected rows in the "Parameters: Remove Baseline and Column Math" dialog

Graphing Bug Fixes

Fixed the issue in which "Mean with SD" was plotted instead of "Mean with SEM" on the grouped graph generated for the Extract and Rearrange analysis if the SEM error bar style was selected as the default in Prism's preferences
Fixed the issue in which a graph generated by the Transform concentrations (X) analysis disappeared after recalculation
Fixed the issue when major and minor grid lines unexpectedly appeared overlapping the symbols of a multiple variables graph
Fixed the issue when the Magic feature did not apply symbol color and transparency formatting on multiple variables graphs
Fixed the issue when the Y-axis numbering was cut on the XY graph copied to the layout sheet if Y ticks were turned off and the numbering font size was large
Fixed the issue when multiple variable heat maps displayed data using deleted metric variables from the data table
Fixed the issue when axes labels on the multiple variables heat map graph were not updated after changing axes variables
Fixed the issue when the color of symbols on the multiple variables graph or cells of the multiple variables heat map graph were unexpectedly altered after applying the custom color of axes via the 'Define Color Scheme' dialog
Fixed the issue when the resizing knobs did not appear on the selected bubble plot axes without ticks
Fixed the issue when the width and height of the text object on the bubble plot were unexpectedly altered after rotation
Fixed the issue when labels of branches on a dendrogram unexpectedly changed their rotation angle from 90 to 45 degrees after switching graph orientation
Fixed the issue in which graphs generated by the Transform concentrations (X) analysis disappeared after recalculation for PZFX/PZF files that had been converted from .prism files
Fixed the issue in when the wrong region of the graph was shaded after adding custom additional ticks and selecting the option "Fill (shade) between this tick and Y=" in the "Format Additional Ticks and Grids" dialog
Fixed the issue when the scale bar did not appear for multiple variables graphs after hiding both the X and Y axes and enabling the scale bar option on the "Format Axes" dialog
(Windows) Fixed the issue when a color added in the "Custom Color" section of the Choose Color dialog was lost after saving a project
(Windows) Fixed the issue when adding tabulation symbols corrupted free text objects on a graph
(Windows) Fixed the issue when data legends on a graph were unexpectedly altered when a graph was copied to MS Office if legends had been hooked to analysis constants
(Windows) Fixed the issue when graph titles of a set of graphs of the same size and scale assigned to the layout unexpectedly appeared unaligned vertically
(Windows) Fixed the issue when it was impossible to change the fill color of bars on the Scatter graph with bars from the contextual menu on the graph
(Windows) Fixed the issue when just one Prism graph appeared instead of an entire layout copied from Prism to MS Word as a linked (OLE) object
(Windows) Fixed the issue when the color set for error bars in the Format Graph dialog for the 'Column mean, error bars & mean connected' graph was not applied
(Windows) Fixed the issue when arrowheads added to arcs drawn on multiple variables graphs were truncated
(Mac) Fixed the issue when a page orientation of a multiple variables graph could be unexpectedly changed by using the 'Page Setup' dialog
(Mac) Fixed the issue when filling patterns of drawing objects on a graph were incorrectly rendered (appeared upside down)
(Mac) Fixed the issue when images imported to a graph were distorted after saving a project in legacy .pzfx/.pzf format
(Mac) Fixed the issue when the appearance of the 'step-up' type survival graph unexpectedly changed to the 'step-down' type if the Y axis title was changed
(Mac) Fixed the issue when the distance for the X-axis title from the axis unexpectedly changed after changing the default X-axis title for XY graphs
(Mac) Fixed the issue when the transparency value defined for the bubble symbol fill color in the Format Graph dialog did not update accordingly while scrolling through the variable groups
(Mac) Fixed the issue when the Y-axis title lost its center justification after updating the "Distance from axis" option in the Format Graph dialog
(Mac) Fixed the issue when the tooltip with coordinates was shown when dragging an object on a graph or layout if the 'Show tooltips' preferences option was turned off
(Mac) Fixed the issue when row and column titles were not updated in the embedded data table on the multiple variables graph after changing them in the data table
(Mac) Fixed the issue when 'Compact Letter Display' labels from another analysis performed on the same data table were not displayed on the graph
(Mac) Fixed the issue when angled fill patterns of drawing objects appeared with wrong angles on multiple variables graph sheets
(Mac) Fixed the issue when unexpected grids appeared on the 'angled brick' fill pattern set for drawing objects on multiple variables graph sheet
(Mac) Fixed the issue when the dendrogram's orientation was unexpectedly changed to the opposite of the one selected in the 'Format graph' dialog after switching between the Graph Inspector's tabs
(Mac) Fixed the issue when closed drawings on a graph unexpectedly appeared with borders even though the borders were disabled in the 'Shapes’ tab of the Graph Inspector
(Mac) Fixed the issue when the border thickness of the gradient legend on a multiple variables graph was not updated after redefining it in the ‘Gradient Legend Settings’ dialog
(Mac) Fixed the issue when the axis label type of the multiple variables heat map graph was not updated on the Data tab of the Graph Inspector after changing it on the Axes tab in the Inspector or in the 'Format Graph' dialog
(Mac) Fixed the issue when data from the final data set of a table was not plotted on a scatter graph with a huge number of points after increasing the default size of the X axis

Prism Cloud-related Bug Fixes

Fixed the issue when unnecessary thin white lines between cells were present on multiple variables heat maps published to Prism Cloud
(Windows) Fixed the issue when the project was not auto-saved while performing the 'Publish' or 'Update' commands while sending the file to Prism Cloud
(Windows) Fixed the issue when the 'Publish' button was enabled for an unsaved project if the clustering sample data was included
(Windows) Fixed the issue when dash-dotted borders of confidence ellipses and convex hulls were shown as solid lines on the graphs published to Prism Cloud
(Mac) Fixed the issue when the Color legend of the multiple variables heat map published to Prism Cloud appeared blank if some values in the data table were missing or excluded
(Mac) Fixed the issue when an altered but not re-saved Prism project was missing the data table, info, and results sheets after publishing to Prism Cloud

Other Bug Fixes

Fixed the crash that occurred when opening a Prism project with Select and Transform analysis if an empty column was previously added or deleted in the source multiple variables data table with categorical variables
Fixed the crash that occurred when clicking the OK button in the 'Parameters: Select and Transform' dialog if a long text was entered in the 'Transform' field of the 'Custom transforms' section
Fixed the issue when it was possible to exceed the sheet count limit in the Prism project by performing analyses that generated graphs
Fixed the issue when the 'Disk or memory error occurred' alert appeared on switching to the results sheet of the Multiple linear regression analysis if the source data table contained the multiline column titles
Fixed the crash that occurred when undoing axes reassignment for multiple variable heat maps
Fixed the issue when the 'Change Graph Type' and 'Format Axes' toolbar icons unexpectedly remained active after the standalone Dendrogram was toggled off
Fixed the issue when files and folders related to the 'child' analysis unexpectedly disappeared from the .prism file bundle after the 'Recalculate All' operation was performed from the 'parent' results sheet
Fixed the issue when a hint that Dendrogram could not be added unexpectedly appeared in the 'Format Graph' dialog if the 'Show Dendrogram' option was unchecked in the 'Format Graph' dialog before saving the file
Fixed the issue when 'The following data objects cannot be displayed...' floating note on an empty graph listed all data objects instead of the currently enabled ones due to incompatible axes
Fixed the crash that would occur when using Hierarchical clustering as a saved method with non-multiple variables data
Fixed the issue when a graph generated by the Transform concentrations (X) analysis disappeared after recalculation in PZFX/PZF files converted from .prism file format
Fixed the crash that would occur when hiding the X or Y axis on a multiple variables graph after the previous operation of hiding the axis was undone
Fixed the issue when controls for the dendrogram were unexpectedly enabled in the "Format Graph" dialog after using the Magic tool
Updated the hint on the "Account" tab of the Prism Settings dialog to manage the details of Prism license and linked accounts
(Windows) Fixed the crash on an attempt to edit a huge (more than a thousand characters) text object on a graph or layout sheet
(Windows) Fixed the freeze and added the progress bar when deleting many sheets from the project
(Windows) Fixed the crash that occurred upon opening the 'Parameters: Simple Logistic Regression' dialog with parameters linked to analysis constants
(Windows) Fixed the freeze or crash that occurred upon switching between sheets or changing analysis parameters if Windows had low free disk space
(Windows) Fixed the issue when values disappeared from the data table in the automatically saved version of the project after changes were made in the 101-th (or next) rows/columns
(Windows) Fixed the issue when changes to the Prism script were not saved within the current .prism file
(Windows) Fixed the issue when Prism was unable to open a project with an analysis that contains a constant from another analysis
(Windows) Fixed the issue when an updated data table title was not automatically propagated to a linked result sheet title
(Windows) Fixed the issue when an unexpected alert about an expired legacy (serial number) license appeared after a user-based license was successfully activated
(Windows) Fixed the issue when misleading row and Y values appeared in a tooltip for data on the grouped graph after adding an empty row in the source data table
(Windows) Fixed the issue when the sheet name and title of graphs created from results of the 'Extract and rearrange' analysis did not update after the response variable was changed in the analysis parameters dialog
(Windows) Fixed the issue when the title of a chained results sheet was not automatically updated according to changing the response variable in the 'Extract and Rearrange' analysis
(Windows) Fixed the issue when the title of the linked results sheet was not automatically updated after renaming the source data table if it was created by a 'Duplicate family' action with renaming
(Windows) Fixed the issue when the Y value was shown on the tooltip for the scatter graph with bars instead of the mean of the current data set
(Windows) Fixed the issue when X-axis labels were unexpectedly shifted on a printed graph when the display scale in the system settings was set bigger than 100%
(Windows) Fixed the issue when the order of the 'Confidence Ellipses' and 'Convex Hulls' sections in the Graph Inspector was unexpectedly changed depending on the order of selecting them in the 'Format Graph' dialog
(Windows) Fixed the issue when the 'Clear' option in the color palette appeared unexpectedly disabled if it was invoked from the contextual menu for the dendrogram graph
(Windows) Fixed the issue when the double '&' symbol appeared in sheet.json files in the Prism file bundle for 'Bias & agreement' and 'Sensitivity & Specificity' results tabs of 'Bland-Altman' and 'ROC Curve' analyses
(Windows) Fixed the issue when no controls for the dendrogram on the heat map appeared on the Legends tab of the Graph Inspector opened by clicking the color legend
(Windows) Fixed the issue when it was impossible to hook constant to a column mean value in the 'Parameters: Simulate Column Data' dialog
(Windows) Fixed the issue when the multiple variables graph page was unexpectedly scrolled to the center after closing the 'Format Graph' dialog
(Windows) Fixed the issue when "Fill Color", "Fill Pattern", "Border Color", and "Border Thickness" were not available in the contextual menu invoked for the bar on the 'Scatter plot with bars' graph type
(Windows) Fixed the issue when the 'Row titles' option unexpectedly appeared in the 'Labels Type' dropdown on the Data tab of the Inspector after changing the Dendrogram orientation
(Windows) Fixed the issue when graph previews in the 'Graph Portfolio' section of the Welcome dialog were not shown if the 'EBWebView' folder in the user's AppData folder had read-only permissions
(Windows) Fixed the crash that would occur when inserting an analysis constant from the "Identify outliers" analysis on a graph
(Windows) Fixed the issue when the "Major ticks interval" field was being truncated in the "Format Axes" dialog
(Windows) Removed the Prism license expiration warning that unexpectedly appeared when clicking on embedded/linked Prism graphs in Microsoft Office documents
(Windows) Fixed the issue when the alert "This file was damaged or truncated" unexpectedly appeared in an attempt to delete a results sheet from the Family section of the Navigator
(Windows) Disabled the "Reverse Size Legend" command in the contextual menu for the color legend of a multiple variables heat map
(Mac) Fixed the issue in which Prism would freeze when attempting to format points on a graph from a data table with big data (over 150 000 values)
(Mac) Fixed the crash that occurred upon undoing or redoing the 'Duplicate Family' command repeatedly
(Mac) Fixed the crash that occurred upon undoing changes made in the 'Clusters appearance' dropdown on the Data tab of the Graph Inspector for a Dendrogram
(Mac) Fixed the crash that occurred upon applying the color scheme for the multiple variables heat map after changing the assignment for X and Y axis variables from categorical to Column/Rows
(Mac) Fixed the issue when example graphs appeared empty after applying the Magic tool with disabled properties ‘Graph origin and appearance” and 'Range ticks of the axis'
(Mac) Fixed the issue when previous column titles instead of renamed ones were used in the names of graph sheets in the Navigator that were generated from the green results sheet
(Mac) Fixed the issue when the custom cell border style on multiple variables heat maps were lost upon saving the file resulting in the cell border being unexpectedly displayed as a solid line in the Graph Inspector and 'Format Graph' dialog
(Mac) Fixed the issue when an unnecessary confirmation alert appeared when changing variable type directly in the multiple variable data table
(Mac) Fixed the issue when the values set for the border thickness of the multiple variables graph gradient legend did not match in the Graph Inspector and the ‘Gradient Legend Settings’ dialog
(Mac) Fixed the issue when the Transparency value set for symbols in the Graph Inspector was not updating automatically when using the transparency slider
(Mac) Fixed the issue when the border thickness of the continuous color legend did not match in the UI of the Graph Inspector and the 'Format graph' dialog
(Mac) Fixed the issue when a file path or file name constants hooked to the graph or layout sheet were not updated after altering
(Mac) Fixed the issue when the thickness of the line/arc/zigzag or borders of the closed drawings on the multiple variables graph sheets did not change according to the Graph Inspector and the contextual menu settings
(Mac) Fixed the issue when values pasted as linked data to the Multiple variables data tables were not updated after excluding these values in the source data table
(Mac) Fixed the issue with the new macOS 15 system window arrangement feature "Move and Resize" in Prism
(Mac) [macOS 15] Fixed the issue when it was impossible to preview Prism documents in the Finder app
(Mac) Fixed the issue when sheets appeared in random order in the Navigator panel after undoing the "duplicate family" action
(Mac) Fixed the crash that occurred when scrolling through the graph section in gallery view mode with many multiple variables heat maps
(Mac) Removed the "Paste A Graph from Another Project As" option from the "File & Printer" tab of Prism's preferences

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