When I try to launch a networked Prism Mac (version 4), I get error code -54.

The error message is not informative, but the problem is probably easy to bypass.

The "server" is meant to be a shared disk drive from which Prism 4 is launched on other computers. Prism 4 Mac gets very mixed up if it is launched first from the server. The simplest solution is just not to run Prism from your server. Or make sure it is launched on at least one other computer before launching it on your server.