KNOWLEDGEBASE - ARTICLE #1840
Correspondence between "classic" (Prism 4) equations and "new" (Prism 5 and later) equations
Prism 5 introduced an entirely new set of equations in Prism to use for nonlinear regression. The older equations are still present in the last category of equations in the list "Classic equations from prior versions of Prism". Here is how they are related:
| Prism 4 and earlier | Equaivalent equation to use with Prism 5 and later | |
| Classic equations | New equation category | Equation name |
| One-site binding (hyperbola) | Binding Saturation | One site -- Specific Binding |
| Two-site binding | Binding Saturation | Two sites -- Specific Binding |
| Sigmoidal dose-respone | Dose-resopnse - Stimulation | log(agonist) vs. response (three paramter) |
| Sigmoidal dose-response (variable slope) | Dose-resopnse - Stimulation | log(agonist) vs. response - Variable slope (four paramter) |
| One site competition | Binding - Competitive | One site - Fit logIC50 |
| Two site competition | Binding - Competitive | Two sites - Fit logIC50 |
| Boltzmann sigmoidal | ---------- (not in new equation set) ---------- | |
| One phase exponential decay | Exponential | One phase decay |
| Two phase exponenetial decay | Exponential | Two phase decay |
| Exponential growth | Exponential | Exponential growth equation |
| Power Series | ---------- (not in new equation set) ---------- | |
| Polynomial (various) | Polynomial | Various |
| Sine wave | Sine waves | Standard sine wave |
| Gaussian | Gaussian | Gaussian |