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It fits four parameters: the bottom and top plateaus of the curve, the EC50 (or IC50), and the slope factor (Hill slope). This curve is symmetrical around ...

https://www.graphpad.com/guides/prism/latest/curve-fitting/

Prism 4 leaves the EC50 blank, but reports the other values. There is an easy fix. From Prism 4, click Change...Analysis parameters. Don't change anything, just ...

GraphPad FAQs

Many log(dose) response curves follow the familiar symmetrical sigmoidal shape. The goal is to determine the EC50 of the agonist - the concentration that ...

https://www.graphpad.com/guides/prism/latest/curve-fitting/

The EC50 (or IC50) refer to a concentration of agonist (or antagonist) required to increase (or reduce) the measured response to half - or 50% - of its maximal ...

https://www.graphpad.com/guides/prism/latest/curve-fitting/

EC50 is the concentration of agonist that gives a response half way between ... Depending on which units Y is expressed in, and the values of Bottom and Top, the ...

https://www.graphpad.com/guides/prism/latest/curve-fitting/

Neubig, personal communication). This term is not very standard, and is a bit misleading as there is nothing absolute about an "absolute EC50". The concept (but ...

GraphPad FAQs

This model fits entire dose-response curves determined in the absence and presence of a modulator. The goal is to learn the affinity of the modulator for ...

https://www.graphpad.com/guides/prism/latest/curve-fitting/

EC50 and LogEC50: EC50 is the concentration of agonist that gives half maximal response in the absence of inhibitor. The logEC50 is in the same units you used ...

https://www.graphpad.com/guides/prism/latest/curve-fitting/

LogEC50 is the logarithm of the EC50 (effective concentration, 50%). With different kinds of variables, this variable is sometimes called ED50 (effective ...

https://www.graphpad.com/guides/prism/latest/curve-fitting/

The EC50 is determined by two properties of the agonist: •How well it binds to the receptor, quantified by the affinity of the drug for binding to its ...

https://www.graphpad.com/guides/prism/latest/curve-fitting/