Median survival time

The median survival time is the time point at which the probability of survival equals 50%. Some things to keep in mind:

•If the probability of survival exceeds 50% at the longest time point, then the median survival time cannot be computed. Prism reports that the median survival is “undefined”. The logrank comparison of curves compares entire curves, and does not compare median survival times. So the P value computed by the logrank test is still valid even if one or both median survival times are undefined

•If the survival curve is horizontal at 50% survival, then the median survival time is not clearly defined. In the survival curve below, the curve is horizontal at Y=50% between 9 and 17 months. Prism follows the suggestion of Machin and reports that the median survival is the average of those two values, or 13 months in this case.

•Prism - like most programs - defines median survival as the time at which the staircase survival curve crosses 50% survival. This is an accurate statement of median survival in the subjects or animals actually included in the data set. The graph on the left below shows how Prism computes median survival (211 days for this example). If you connected the survival times with point-to-point lines rather than a staircase, you’d find that the line may intersect Y=50% at an earlier time, and thus you’d come up with a different value for median survival (193 days in the example on the right below). This would make sense if you were trying to predict median survival for future patients. Prism does not do this, as it is not standard