Kinetics of binding

curvefit.com was created by GraphPad Software, Inc. Send comments or questions to the author of these pages, Dr. Harvey Motulsky, president of GraphPad Software.

In April 2003, GraphPad released Prism 4 and published Fitting Models to Biological Data using Linear and Nonlinear Regression. This book includes all the information that comprises curvefit.com, and much more. You can read this book as a pdf file.

We wrote the book Many researchers use nonlinear regression more than any other statistical tool. Despite this popularity, there are few places to learn about nonlinear regression. Most introductory statistics books focus only on linear regression, and entirely ignore nonlinear regression. The advanced statistics books that do discuss nonlinear regression tend to be written for statisticians, exceed the mathematical sophistication of many scientists, and lack a practical discussion of biological problems. That's why GraphPad's Harvey Motulsky (together with Arthur Christopoulos) wrote Fitting Models to Data Using Linear and Nonlinear Regression. This 350-page book comes with Prism and will soon be available in bookstores (to be published by Oxford University Press). You can browse the entire book as a pdf file (free online).

Short booklets

If you aren't quite ready to check out a 350-page book, view these concise booklets:

• The GraphPad Guide to Nonlinear Regression.
• The GraphPad Guide to Radioligand Binding.

Resource Library

We created the GraphPad Resource Library to help biologists (and other scientists) learn about data analysis. This "library" contains articles and manuals written by GraphPad, as well as links to web sites and books written by others. Please email us suggestions (or corrections) to improve this growing resource.